Synthesis and Bioactivity of a Brasilicardin A Analogue Featuring a Simplified Core.
نویسندگان
چکیده
An analogue 2 of Brasilicardin A, 1 (BraA), a potent immunosuppressive and cytotoxic agent, was synthesized in which the natural tricyclic skeleton was replaced with a synthetically more accessible substituted tetrahydronaphthalene core. BraA, this analogue (BraL), and cyclosporine A were tested for their ability to inhibit the proliferation of human T cells upon CD3/CD28 activation. Although BraL did not impact T cell activation over the dose range tested, this study shows the inhibitory activity of BraA on human T cells for the first time.
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عنوان ژورنال:
- Organic letters
دوره 17 14 شماره
صفحات -
تاریخ انتشار 2015